Find the largest open file through lsof

sudo lsof | sort -n -k 8 -u -r | head -n 2

Reference

sort help

$ sort --help
Usage: sort [OPTION]... [FILE]...
  or:  sort [OPTION]... --files0-from=F
Write sorted concatenation of all FILE(s) to standard output.

With no FILE, or when FILE is -, read standard input.

Mandatory arguments to long options are mandatory for short options too.
Ordering options:

  -b, --ignore-leading-blanks  ignore leading blanks
  -d, --dictionary-order      consider only blanks and alphanumeric characters
  -f, --ignore-case           fold lower case to upper case characters
  -g, --general-numeric-sort  compare according to general numerical value
  -i, --ignore-nonprinting    consider only printable characters
  -M, --month-sort            compare (unknown) < 'JAN' < ... < 'DEC'
  -h, --human-numeric-sort    compare human readable numbers (e.g., 2K 1G)
  -n, --numeric-sort          compare according to string numerical value
  -R, --random-sort           shuffle, but group identical keys.  See shuf(1)
      --random-source=FILE    get random bytes from FILE
  -r, --reverse               reverse the result of comparisons
      --sort=WORD             sort according to WORD:
                                general-numeric -g, human-numeric -h, month -M,
                                numeric -n, random -R, version -V
  -V, --version-sort          natural sort of (version) numbers within text

Other options:

      --batch-size=NMERGE   merge at most NMERGE inputs at once;
                            for more use temp files
  -c, --check, --check=diagnose-first  check for sorted input; do not sort
  -C, --check=quiet, --check=silent  like -c, but do not report first bad line
      --compress-program=PROG  compress temporaries with PROG;
                              decompress them with PROG -d
      --debug               annotate the part of the line used to sort,
                              and warn about questionable usage to stderr
      --files0-from=F       read input from the files specified by
                            NUL-terminated names in file F;
                            If F is - then read names from standard input
  -k, --key=KEYDEF          sort via a key; KEYDEF gives location and type
  -m, --merge               merge already sorted files; do not sort
  -o, --output=FILE         write result to FILE instead of standard output
  -s, --stable              stabilize sort by disabling last-resort comparison
  -S, --buffer-size=SIZE    use SIZE for main memory buffer
  -t, --field-separator=SEP  use SEP instead of non-blank to blank transition
  -T, --temporary-directory=DIR  use DIR for temporaries, not $TMPDIR or /tmp;
                              multiple options specify multiple directories
      --parallel=N          change the number of sorts run concurrently to N
  -u, --unique              with -c, check for strict ordering;
                              without -c, output only the first of an equal run
  -z, --zero-terminated     line delimiter is NUL, not newline
      --help     display this help and exit
      --version  output version information and exit

lsof help

$ lsof -h
lsof 4.89
 latest revision: ftp://lsof.itap.purdue.edu/pub/tools/unix/lsof/
 latest FAQ: ftp://lsof.itap.purdue.edu/pub/tools/unix/lsof/FAQ
 latest man page: ftp://lsof.itap.purdue.edu/pub/tools/unix/lsof/lsof_man
 usage: [-?abhKlnNoOPRtUvVX] [+|-c c] [+|-d s] [+D D] [+|-E] [+|-e s] [+|-f[gG]]
 [-F [f]] [-g [s]] [-i [i]] [+|-L [l]] [+m [m]] [+|-M] [-o [o]] [-p s]
 [+|-r [t]] [-s [p:s]] [-S [t]] [-T [t]] [-u s] [+|-w] [-x [fl]] [--] [names]
Defaults in parentheses; comma-separated set (s) items; dash-separated ranges.
  -?|-h list help          -a AND selections (OR)     -b avoid kernel blocks
  -c c  cmd c ^c /c/[bix]  +c w  COMMAND width (9)    +d s  dir s files
  -d s  select by FD set   +D D  dir D tree *SLOW?*   +|-e s  exempt s *RISKY*
  -i select IPv[46] files  -K list tasKs (threads)    -l list UID numbers
  -n no host names         -N select NFS files        -o list file offset
  -O no overhead *RISKY*   -P no port names           -R list paRent PID
  -s list file size        -t terse listing           -T disable TCP/TPI info
  -U select Unix socket    -v list version info       -V verbose search
  +|-w  Warnings (+)       -X skip TCP&UDP* files     -Z Z  context [Z]
  -- end option scan     
  -E display endpoint info              +E display endpoint info and files
  +f|-f  +filesystem or -file names     +|-f[gG] flaGs 
  -F [f] select fields; -F? for help  
  +|-L [l] list (+) suppress (-) link counts < l (0 = all; default = 0)
                                        +m [m] use|create mount supplement
  +|-M   portMap registration (-)       -o o   o 0t offset digits (8)
  -p s   exclude(^)|select PIDs         -S [t] t second stat timeout (15)
  -T qs TCP/TPI Q,St (s) info
  -g [s] exclude(^)|select and print process group IDs
  -i i   select by IPv[46] address: [46][proto][@host|addr][:svc_list|port_list]
  +|-r [t[m<fmt>]] repeat every t seconds (15);  + until no files, - forever.
       An optional suffix to t is m<fmt>; m must separate t from <fmt> and
      <fmt> is an strftime(3) format for the marker line.
  -s p:s  exclude(^)|select protocol (p = TCP|UDP) states by name(s).
  -u s   exclude(^)|select login|UID set s
  -x [fl] cross over +d|+D File systems or symbolic Links
  names  select named files or files on named file systems
Anyone can list all files; /dev warnings disabled; kernel ID check disabled.